Optimal matrix rigidity for stress-fibre polarization in stem cells
نویسندگان
چکیده
منابع مشابه
Matrix rigidity regulates microtubule network polarization in migration.
The microtubule organizing center (MTOC) frequently polarizes to a position in front of the nucleus during cell migration, but recent work has shown conflicting evidence for MTOC location in migratory polarized cells. Here, we show that subcellular localization of the MTOC is modulated by extracellular matrix stiffness. In scratch wound assays as well as single cell migration of mesenchymal ste...
متن کاملMatrix Rigidity
The rigidity of a matrix M is the function R M (r), which, for a given r, gives the minimum number of entries of M which one has to change in order to reduce its rank to at most r. This notion has been introduced by Valiant in 1977 in connection with the complexity of computing linear forms. Despite more than 20 years of research, very little is known about the rigidity of matrices. Nonlinear l...
متن کاملRigidity and lack of rigidity for solenoidal matrix fields
We study the problem of identifying conditions under which a divergence free matrix field takes values in some prescribed sets of matrices K. We treat in detail the case when K is made of two or three matrices. Our results are parallel to those on curl free matrices. In that case Ball and James showed rigidity when K is made of two matrices and Tartar proved lack of rigidity when K is made of f...
متن کاملIn Vivo Tracing of Human Umbilical Cord Matrix Stem Cells Useing MRI
Purpose: Human umbilical cord matrix (UCM) (Wharton jelly) stem cells labeling are tracking by MRI. Materials and Methods: After 48 hours incubation with USPIO human umbilical cord matrix (UCM) stem cells were labeled with USPIO by the means of receptor-mediated endocytosis. Prussian blue staining and Atomic absorption spectroscopy were performed to identify and show the iron oxide nanoparticle...
متن کاملP158: Targeting of Microglial M1/M2 Polarization Through Stem Cells Therapy as A Promising Candidate in Traumatic Brain Injury (TBI)
Traumatic brain injury is a serious global health problem with irreversible high morbidity and disability and Because of its unknown pathophysiological mechanisms, efficient therapeutic approaches to improve the poor outcome and long-term impairment of behavioral function are still remains lacking. The microglial cells are the resident macrophage cells of the brain and have M1/M2 phenotype, for...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Physics
سال: 2010
ISSN: 1745-2473,1745-2481
DOI: 10.1038/nphys1613